"Working memory network sequences and neuropathological dynamics"Mark bordner 博士（美國MIND研究所）-2012.11.4

時間：2012年11月4日 13:30

地點：理科大樓A510

報告題目：Working memory network sequences and neuropathological dynamics

報告人：Mark bordner 博士 美國MIND研究所

報告人簡介：Ph.d本科畢業于美國匹茲堡大學，加州大學洛杉磯分校獲得博士學位。曾在加州大學洛杉磯分校精神病學和生物行為科學系，加州大學埃文分校物理系任職，現擔任美國MIND研究所所長以及匹茲堡大學數學系和約翰霍普金斯神經外科系兼職教授職務。研究方向：包括神經網絡的數學模型、工作記憶數學模型的建立，以及研究癲癇等神經疾病的機制。

報告簡介：Persistent activation of neuronal populations in recurrent networks of cortico-cortical connections has been implicated as the substrate of working memory.   In addition to persistent activation of neuronal populations, temporal patterns of activity which repeat above chance levels in the brain have been reported experimentally, and this is thought to subserve functions such as movement, speech and rhythms.   A biologically plausible model of working memory is presented incorporating densely interconnected excitatory neurons and asymmetric Hebbian plasticity which reproduces the persistent activity of neuronal populations observed during working memory in the cortex.  The model is also capable of learning and reproducing complex sequence activity from external stimuli with implications for working memory oscillations and rhythm generation.    It will then be examined how specific changes in the architecture or parameters of the working memory network (e.g. reductions in network inhibition) lead to dynamics which may be associated with different neuropathologies including epilepsy, schizophrenia and obsessive compulsive disorders.  It will be shown how these different pathological dynamics may arise from similar or the same mechanisms acting in the recurrent working memory networks.