華東師范大學 腦功能基因組學教育部重點實驗室 PI
華東師范大學 生命科學學院 教授
Email: tlshi@bio.ecnu.edu.cn
研究方向
1. 臨床信息標準化以及基因型表型的關聯研究；
2. 高通量數據（測序數據和蛋白質組學數據）分析及方法學開發；
3. 整合臨床信息和多組學數據的疾病基因及機理研究，生物分子標記的發現；
4. 基因調控網絡的研究和蛋白質相互作用網絡的研究；。
個人簡歷
教育經歷:
1993.9 – 2000.1 分子生物學博士，美國Louisville大學
1998.1 – 1999.8 計算機碩士，美國Louisville大學
1989.9 – 1992.7 植物生理學碩士，中科院上海植物生理研究所
1984.9 – 1989.7 生物學學士，湖南師范大學生物系
1979.9 – 1982.7 化學專業，湖南文理學院
工作經歷:
2008.11 –至 今 華東師范大學生命科學學院 特聘教授
2002.6 - 2008.10 中科院上海生命科學研究院 生物信息學中心 課題組長
2004.4 - 2007.7 上海大學生物信息學中心 兼職教授
2004.4 - 2009.7 東北林業大學生命科學學院 兼職教授
學術任職/人才獲獎
1. 中國遺傳學會大數據分會理事；
2. 上海市生物信息學學會理事；
3. 上海市植物生理學會理事；
4. 上海市基因健康專委會委員
5. 上海市計算機生物信息學專委會委員；
6. Science China – Life Sciences雜志常務編委；
7. Pediatric Investigation 雜志副主編。
代表性成果
1. Jia JM, An ZX, Ming Y, Guo YL, Li W, Liang YX, Guo DM, Li X, Tai J, Chen G, Jin YQ, Liu ZM, Ni X, and Shi TL* eRAM: encyclopedia of rare disease annotations for precision medicine. Nucleic Acids Research 2017, Accepted
2. Jia JM, An ZX, Ming Y, Guo YL, Li W, Liang YX, Guo DM, Li X, Tai J, Chen G, Jin YQ, Liu ZM, Ni X, and Shi TL* PedAM: a database for Pediatric Disease Annotation and Medicine. Nucleic Acids Research 2017, Accepted
3. Huang L, Xie D, Yu Y, Liu H, Shi Y, Shi TL*, C Wen CP. TCMID 2.0: a comprehensive resource for TCM. Nucleic Acids Research 2017, Accepted
4. Feng J, Ding C, Qiu N, Ni X, Zhan D, Liu W, Xia X, Li P, Lu B, Zhao Q, Nie P, Song L, Zhou Q, Lai M, Guo G, Zhu W, Ren J, Shi TL*and Qin J Firmiana: Towards a One-stop Proteomic Cloud Platform for Data Processing and Analysis. Nature Biotechnology, 35:409-412, 2017
5. Cao R, Shi Y, Chen S, Ma Y, Chen J, Yang J, Chen G and Shi TL* dbSAP: single amino-acid polymorphism database for protein variation detection. Nucleic Acids Research 45 (D1): D827- D832, 2017
6. 10.1007/s11427-015-0348-5, 2017
7. Lv Q, Lan Y, Shi Y, Wang H, Pan X, Li P and Shi TL* AtPID: a genome-scale resource for genotype–phenotype associations in Arabidopsis. Nucleic Acids Research 45 (D1): D1060-D1063, 2017
8. Hu PZ, Shen ZC, Tu HP, Zhang L, Shi TL* Integrating multiple resources to identify specific transcriptional cooperativity with a Bayesian approach. Bioinformatics, 30 (6): 823-830 , 2014
9. Chen G, Wang C, Shi LM, Tong WD, Qu XF, Chen JW, Yang JM, Shi CP, Chen L, Zhou PY, Lu BX, Shi TL* Comprehensively identifying and characterizing the missing gene sequences in human reference genome with integrated analytic approaches. Human Genetics, 132(8):899-911, 2013
10. Chen G, Wang C, Shi LM, Qu XF, Chen JW, Yang JM, Shi CP, Chen L, Zhou PY, Ning BT, Tong WD, Shi TL* Incorporating the human gene annotations in different databases significantly improved transcriptomic and genetic analyses. RNA, 19(4): 479-489, 2013
11. Xue RC, Fang Z, Zhang MX, Yi ZH, Shi TL* TCMID: Traditional Chinese Medicine Integrative Database for Herb Molecular Mechanism Analysis. Nucleic Acids Research 41(D1): D1089-D1095, 2013
12. Li P, Zang W, Li Y, Xu F, Wang J and Shi TL*. AtPID: the overall hierarchical functional protein interaction network interface and analytic platform for Arabidopsis. Nucleic Acids Res. 39(Database Issue): D1130-1133, 2011
13. He B, Qiu X, Li P, Wang L, Lv Q and Shi TL*. HCCNet: an integrated network database of hepatocellular carcinoma. Cell Res 20:732-734, 2010
14. Yu Q-B, Li G, Wang G, Sun J-C, Wang P-C, Wang C, Mi H-L, Ma W-M, Cui J, Cui Y-L, Chong K, Li Y-X, Li Y-H, Zhao Z-M, Shi TL*, Yang Z-N Construction of a chloroplast protein interaction network and functional mining of photosynthetic proteins in Arabidopsis thaliana. Cell Res 18: 1007-1019, 2008
15. Li J, Liu Z-J, Pan Y-C, Liu Q, Fu X, Cooper N, Li Y-X, Qiu M-S, Shi TL* Regulatory Module Network of bHLH Transcription Factors in Mouse Brain. Genome Biol. Vol.8 (11):R244, 2007